Potassium Permanganate Oxidation Tutorial
General Scheme of Potassium Permanganate Oxidation
Potassium Permanganate can be used to oxidize primary alcohols to carboxylic acids and secondary alcohols to ketones. This method is harsh and is also suitable for acidic harsh conditions and acid sensitive compound conditions.1
Summary
The reaction entry summary. Find the general scheme and full summarized mechanisms here.
General Scheme
This section briefly summarizes what can and cannot undergo reactions.
- 1° Alcohols (Primary) get oxidized to Carboxylic Acids.
- 2° Alcohols (Secondary) get oxidized to Ketones.
- 3° Alcohols (Tertiary) do not get oxidized at all.
Other Conditions
- Potassium Permanganate can be used alongside sulfuric acid to oxidize 1° Alcohols (Primary) to Carboxylic Acids
General Mechanism
This section briefly summarizes steps to find the product and perform the mechanisms.
Quick steps to finding the product for any alcohol
- Identify the reagents.
- Assign side chains (non alcohol part).
- Selectively convert Alcohol to correct product based on alcohol type. Nothing else.
- Keep the side chains (non alcohol part) the same and piece together the full molecule together again.
Full Primary Alcohol to Carboxylic Acid Mechanism
Full Secondary Alcohol to Ketone Mechanism
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Always remember to repeatedly practice your mechanisms and getting your reagents correct. Take advantage of our materials and/or keep practicing on a whiteboard or paper until you get it right every single time.
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